Protein Structure for Human Coagulation Factor V

All structural analysis of the missense variants presented within this database uses the 3.3A FV cryo-EM structure 7KVE taken from the RCSB Protein Data Bank.
Structure 7KVE consists of all A and C domains of human FV with the large majority of the B domain disordered (Ruben et al, Blood 2021 Vol 137(22): 3137-3144 PMID No 33684942).